carbenoxolone attenuated morphine-induced withdrawal syndrome in rat
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منابع مشابه
The role of spinal serotonergic system in morphine withdrawal syndrome in the rat
Previous pharmacological studies have implicated serotonergic brain systems in opiate withdrawal syndrome. Increased brain 5-HT release is associated with the development of physical dependence to morphine. Specific serotonin reuptake inhibitors, such as fluvoxamine and sertraline reduce the severity of naloxone precipitated opioid withdrawal syndrome. Other studies have shown that 5-HT system ...
متن کاملThe role of spinal serotonergic system in morphine withdrawal syndrome in the rat
Previous pharmacological studies have implicated serotonergic brain systems in opiate withdrawal syndrome. Increased brain 5-HT release is associated with the development of physical dependence to morphine. Specific serotonin reuptake inhibitors, such as fluvoxamine and sertraline reduce the severity of naloxone precipitated opioid withdrawal syndrome. Other studies have shown that 5-HT system ...
متن کاملEffect of Tizanidine, Rilmenidine, and Yohimbine on Naloxon-Induced Morphine Withdrawal Syndrome in Mice
In this study using clonidine (a mixed ?2 /I1 receptors agonist), tizanidine (pure ?2-receptor agonist), rilmenidine (I1 receptor agonist) and yohimbine (?2-receptor antagonist), we tried to clarify the role of imidazoline and ?2-receptors in morphine withdrawal syndrome. Morphine-dependence was induced by administration of increasing doses of morphine in mice. After the last administration of ...
متن کاملEffect of Tizanidine, Rilmenidine, and Yohimbine on Naloxon-Induced Morphine Withdrawal Syndrome in Mice
In this study using clonidine (a mixed ?2 /I1 receptors agonist), tizanidine (pure ?2-receptor agonist), rilmenidine (I1 receptor agonist) and yohimbine (?2-receptor antagonist), we tried to clarify the role of imidazoline and ?2-receptors in morphine withdrawal syndrome. Morphine-dependence was induced by administration of increasing doses of morphine in mice. After the last administration of ...
متن کاملEffect of reversible inactivation of locus ceruleus on naloxone-induced withdrawal syndrome in paragigantocellular neurons in morphine-dependent rats
In this study, the effect of reversible inactivation of locus ceruleus (LC) on naloxone- induced withdrawal syndrome in paragigantocellular (PGi) neurons in morphine- dependent rats was investigated. For inactivation of LC, 1 µl of lidocaine (2%) was used and for induction of withdrawal syndrome, naloxone hydrochloride (2 mg/kg) was injected systemically. The results showed that in dependent gr...
متن کاملEffect of Nimodipine on Morphine-related Withdrawal Syndrome in Rat Model: An Observational Study
OBJECTIVE To observe the effect of L-type calcium channel blocker like nimodipine on morphine's withdrawal when it was administered continuously along with morphine versus a single bolus dose of nimodipine, which was administered at the end of the experiment before the precipitation of withdrawal reaction in morphine-dependent rats. MATERIALS AND METHODS Four groups of adult male Wistar rats ...
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عنوان ژورنال:
research in pharmaceutical sciencesجلد ۷، شماره ۵، صفحات ۰-۰
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